Mitochondrial calcium signalling plays a fundamental role in cellular homeostasis by modulating energy production and activating key metabolic enzymes. Calcium ions (Ca2+) are dynamically exchanged ...

Mitochondrial dysfunction manifests as structural damage (swelling, cristae rupture, increased volume/decreased numerical density), energy metabolism abnormalities (reduced COX and Complex I-III ...

Boosting mitochondrial calcium by inhibiting the LETM1 protein enhances long-term memory formation in flies and mice.

Mitochondria are essential for cell survival, repair, and adaptation. Not only do they generate most of the energy needed ...

Researchers uncover how cells internalize transplanted mitochondria, paving the way for new energy-restoring therapies for Parkinson’s and Alzheimer’s.

A Parkinsonian mystery—how PINK1 locks onto malfunctioning mitochondria—now has a structural solution. Researchers at the University of Melbourne led by Sylvie Callegari, Alisa Glukhova, and David ...

A protein that helps regulate calcium signaling within heart cells could play a key role in preventing chronic heart failure, according to University of Utah Health scientists. Photo credit: Getty ...

Newly published CU Boulder research reveals previously unknown qualities of a gene vital to a cell’s mitochondrial structure and function A key takeaway from first-year biology is that mitochondria ...

Acute pancreatitis (AP) remains a major medical challenge, with high morbidity and no approved drug that directly alters its course. Recent advances reveal that the earliest and most critical trigger ...